Soran University Biology Module Specification 1. Module Title: Genetics 2. Module Code: 3. Module Level: third year 4. Module Leader: Narmeen Abdul Samad Ismaiel 5. Teaching Semester: First 6. Credit Rating for the module: 3 7. Prerequisites and co-requisites: general biology& cell biology 8. Module Summary The lectures summaries all the general information you need to guide you during the third stage of your selected course. This booklet also describes in details the content of genetic, the names of academic staff who will teach the unit, and what you will be expected to do to make sure your success in this unit. Genetic is the science of the heredity .The discipline has a rich history and involves investigations of molecules, cells, organisms, and populations, using many different experimental approaches. Not only does genetic information play a significant role during evolution, but its expression influences the function of individuals at all levels. The genetic unifies the study of biology and has a profound impact on human affairs. 9. Module Aims It is our purpose in this course to introduce and describe the processes and patterns of inheritance; we present a broad outline of the topics to be covered of some of the more important historical advancements leading to our current understanding of genetics. Give you a firmer foundation in those basics of genetics so that you can be that much more conversant and thoughtful about some major current topics in genetics. This class will provide you with an understanding of the principles and concepts of genetics Specific topics are listed below. 10. Learning Outcomes After completion of this course the student will be able to: * Understand that genes are discrete units that control the appearance of an organism. * To understanding Mendel’s rules of inheritance segregation and independent assortment and how they relate to cytogenetic. * design and explain an experiment that uses test crosses to determine genotypes. * compare and contrast incomplete dominance and co-dominance and predict their modes of inheritance * To understand that dominance is a function of the interaction of alleles; similarly, epistasis is a function of the interaction of nonallelic genes. * To analyze the cause of sex determination in various organisms. * Analyze the inheritance patterns of traits that loci on the sex chromosome control. * Learned approaches which can be used for the diagnosis of genetic disease and carrier detection. * Types of mutations, mutagens and repair systems. * Preparation of metaphase chromosome and sperm abnormalities in mice (Mus musculus) & karyotype analysis. * preparation of Polytene chromosome. * Apply basic knowledge of practical approaches and techniques 11. Syllabus [A list of the knowledge content of the module] 12. Assessment Strategy Examination and grading Theory (70% of total course marks) * The average of 2 written examinations/assessments will stand for 25% of the total course marks. * A Final examination will stand for the remaining 45% of total course marks. Practical (30% of total course marks) * The average of 2 written examinations will stand for 10% of the total course marks. * A final examination will stand for 15% of the total course marks. * The exam has 10 marks (mean of two examination), the attendance, classroom activities, and Daily quiz: counting 5 marks. 13. Summary description of assessment [A table summarizing the assessment components of the module] Assessment TypeDescription of Item% WeightingGradingTariffWeek dueEXMTheory 60%EXMPractical 30%GWKQuizes 5%PRSTutorial 5% 14. Learning Session Structure 1 x 2 h lectures and 1 x 3 h laboratory sessions per week. 15. Learning and Teaching Methods Different forms of teaching will be used to reach the objectives of the course: power point presentations for the head titles and definitions and summary of conclusions, movies, photomicrographs, besides worksheet will be designed to let the chance for practicing on several aspects of the course in the classroom, furthermore students will be asked to collect samples. There will be classroom sample and slide drawing, discussions and the laboratory notes will give enough background to test, solve, analyze, and evaluate problems sets, and Literature discussions will utilize small group discussions following by classroom presentation and discussion throughout the course. 16. Scheme of Work WeekDelivery MethodContentLearning MaterialsLearning OutcomesForm of Assessment1LectureHistory of geneticpptthe genetic theories 2LectureMendelian geneticspptMendel’s experimental methods, Mendel’s 1st and 2nd laws, Punnett square,test cross and back cross.3LectureType ofdominanceppt: Dominant/ recessive, incomplete dominance, Codominance, Overdominance, Lethal genes, Multiple alleles 4LectureEpistasis: ppt: Dominant epistasis , RecessiveEpistasis, , Duplicate dominant genes, Duplicate recessive genes, Dominant and recessive interaction, Gene interactions5LectureSex determination pptGenetic mechanisms of sex determination, chromosomal basis of sex determination6Lecturesex linked Inheritance (X-linked recessive and dominant traits): pptVariation of sex-linkage, Pseudoautosomal Inheritance, Sex linked in Drosophila , X-linked recessive trait and examples, X-linked dominant trait and examples.7EXAM8Y-linked traits, sex limited traits and Sex influenced traits, pptY-linked inheritance and their examples, Sex influenced traits, sex limited traits and their examples9LectureChromosome aberrations, variation in Chromosome number: pptclassification of chromosomes, aneuploidies of the sex chromosomes, aneuploidies of the somatic chromosomes, aneuploidy polyploidy10LectureVariation in chromosome structure:pptDeficiencies/Deletions; Duplications ;Inversions; Translocations and their examples11LectureMutation;Types of mutation.pptDefinition, What Are Mutations?,causes and types, Are mutations helpful or harmful?, single base-pair mutations,point mutation, substitutions, inversion, additions, Deletions,tautormeric shifts 12Lecture Mutagenic agents and the mechanisms of mutation, pptMutation Physical agents, ionizing and nonionizing radiation, chemical agents, nitrous acid, hydroxylamine, base analogue mutagen, alkylating agents 13LectureGenetics of cancer: pptCancer is a genetic disease, cell cycle regulation and cancer, causes of cancer, cancer and environment14examPractical lecture WeekExperiment1Introduction to genetic, genetic concept terms2Cytological basic for transmission genetics- mitosis 3Study of meiosis division in eukaryotes 4Culture of drosophila for genetic experiment 5Polytene chromosome from drosophila –salivary gland 6Mutation induction in Drosophila melanogaster 7First exam 8Using chromatography to identify the eye mutation of Drosophila melanogaster9Finger prints and palmer dermatology 10Study of sex chromatin in human cells11Metaphase chromosome preparation 12Sperm preparation 13Isolation of Auxotrophic mutants and replica plating technique14Final exam 17. Bibliography (or Literature) 1-Tamarin, R.H. (2002). Principles of genetics (7th edi.). Mc Graw Hill. 2-Klug, W. S,Cumming.M.R. and Spencer.C.A. (2012). Concept of Genetics(10th edi.). pearson Hall. 3-,Cumming.M.R.. (1997). Concept of Genetics(6th edi.). printice Hall. 4-dyer.B. D. (2009). Bases of Genetics.LLC. 5. Schleif.R. (1993). Genetics and molecular biology. (second edi.). 6- Kaplan, B.J. (1978) Preparation of the normal karyotype (workbook). hicago: American Society of Clinical Pathologists. 7-Mertens, T.R. & Hammersmith, R.L. (2014). Genetics: Laboratory Investigations. (17thedi.). Prentice Hall, Englewood Cliffs, NJ. 8-Adem.M.A. (2006). Molecular biology and applied Genetics. MOLECULAR BIOLOGY AND APPLIED GENETICS 1